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It took 12 years for Allison Tuckman to get an accurate diagnosis of polycystic ovary syndrome, then another 10 to find a treatment to help keep her most severe symptoms in check. Now that she’s finally found a drug that works, the Official The Cure Wearing Omar Comin’ Shirt moreover I will buy this 44-year-old from Manalapan, New Jersey, says there’s no going back. “I’ll be taking it ‘till the end of time,” she said. That medication happens to be semaglutide, the same drug in high demand largely for its effects on weight loss. It’s approved under the name Ozempic for Type 2 diabetes and under the name Wegovy for weight loss. Semaglutide falls into a class of drugs called GLP-1 agonists, which also includes the diabetes drugs Mounjaro and Victoza, among others. Since the drugs flooded the scene, there have been reports of other potential uses for them, to treat conditions ranging from PCOS to Alzheimer’s, Parkinson’s, addiction, alcohol use disorder, liver disease and possibly cancer. But proving they work for each individual condition means spending years, and a tremendous amount of
resources, to conduct meticulous laboratory research and large clinical trials. It also requires access to a reliable supply of these drugs, which is far from a given amid widespread shortages. “Unfortunately, because of the Official The Cure Wearing Omar Comin’ Shirt moreover I will buy this shortage of supply, Novo Nordisk is focused on manufacturing the drugs for clinical care and not for research studies,” said Dr. Lorezo Leggio, the clinical director of the National Institute on Drug Abuse at the National Institutes of Health, who has been studying these drugs as a potential treatment for addiction and alcohol use disorder. These constraints have meant the evidence required to get the Food and Drug Administration, insurance providers and even the pharmaceutical companies on board with these new uses has lagged behind the personal experiences of people like Tuckman who say they’ve seen it firsthand: the drugs work. “These anecdotes of people reporting the beneficial effects of semaglutide are very welcome, but they are not the end of the story,” Leggio said. “Medication development needs rigorous science with gold-standard approaches such as clinical trials.” Does Ozempic work for PCOS? Although GLP-1 agonists aren’t FDA-approved to treat polycystic ovary syndrome, Tuckman has been prescribed Ozempic off-label for three years. Over that time, Tuckman said the drug has helped address the more serious PCOS complications, including her body’s excess insulin production, high blood pressure and high cholesterol. Since taking Ozempic, her blood sugar has stabilized and she’s felt less of the debilitating exhaustion that used to make lifting her head from her pillow a Herculean task. An estimated 5 million women in the U.S. have PCOS, a poorly understood and often misdiagnosed condition that can cause women to produce excess testosterone. This can mean painful, heavy or irregular periods, infertility, excess facial and body hair, severe acne, and small cysts on the ovaries. This hormonal imbalance can also cause metabolic complications. Allison Tuckman has been taking Ozempic off-label
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